Epitalon

Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed in the 1990s by Khavinson and colleagues based on the amino acid composition of the natural pineal extract Epithalamin. The original research program was focused on age-related pineal gland physiology and circadian regulation.

In vitro research has reported activation of telomerase reverse transcriptase (hTERT) in somatic cell cultures, with corresponding effects on telomere length over multiple passages. Studies on pinealocyte cultures have reported modulation of melatonin biosynthesis. Effects on circadian rhythm have been observed in rodent models. The peptide is short, with minimal secondary structure; mechanistic specificity at the molecular target level remains an active area of literature debate.

Used in cell-culture telomere biology studies, pineal-pinealocyte research, and aging models in rodents. Frequently referenced in geroscience and circadian-biology research literature.

Every batch ships with a third-party Certificate of Analysis documenting identity, lot-specific HPLC purity, mass spectrometry confirmation, and storage conditions. The COA is downloadable from the buyer's account dashboard and QR-linked on the vial label. Purity claims are per lot, not per product — see the FAQ for the framing.

Sold under one of two B2B buyer categories: research institutions for in vitro work under the RUO designation, or licensed 503A compounding pharmacies as an API for patient-specific compounded preparations under USP <797> or <795>. Accounts are manually reviewed; pending accounts cannot place orders or view pricing.

The full regulatory framing, including what we are not (we are not a 503B outsourcing facility and do not compound finished drugs), is in the disclaimer.